Yes NetCDF is supported by xarray (see http://xarray.pydata.org/en/stable/io.html), so it will be possible to save data to a file with xframe and load that file with xarray (and vice versa).

We also plan to implement Python bindings for xframe, so that we can have in-memory interchange between xarray and xframe. We should be able to operate on data in-place (thanks to xtensor-python), additional work might be required to avoid copy of coordinates.